What to Expect When Visiting a Spravato Treatment Center: A Step-by-Step Guide If you’re considering Spravato (esketamine) for treatment-resistant depression, you may be wondering what actually happens during a treatment session. The process is unlike picking up a prescription at a pharmacy — Spravato is administered in a clinical setting under medical supervision. Knowing what … What to Expect When Visiting a Spravato Treatment Center: A Step-by-Step Guide